Neuropsychological functions in progressive supranuclear palsy, multiple system atrophy and Parkinson's disease.

Significance of apparent diffusion coefficient measurement for the differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and Parkinson's disease: evaluation by 3.0-Tesla MR imaging

Free-water imaging in Parkinson's disease and atypical parkinsonism.

Conventional single tensor diffusion analysis models have provided mixed findings in the substantia nigra of Parkinson's disease, but recent work using a bi-tensor analysis model has shown more promising results. Using a bi-tensor model, free-water values were found to be increased in the posterior substantia nigra of Parkinson's disease compared with controls at a single site and in a multi-si...

Neuroimaging in Parkinsonism: a study with magnetic resonance and spectroscopy as tools in the differential diagnosis.

The differential diagnosis of Parkinsonism based on clinical features, sometimes may be difficult. Diagnostic tests in these cases might be useful, especially magnetic resonance imaging, a noninvasive exam, not as expensive as positron emission tomography, and provides a good basis for anatomical analysis. The magnetic resonance spectroscopy analyzes cerebral metabolism, yielding inconsistent r...

Genetics of Parkinson's Disease and Other Diseases of the Extrapyramidal System

Parkinson's disease is a disorder of the extrapyramidal system. Other diseases causing extrapyramidal disorders, with the exception of Parkinson’s disease, are called atypical parkinsonism or parkinsonism plus. These diseases include: multiple system atrophy, MSA; progressive supranuclear palsy, PSP; corticobasal degeneration, CBD; dementia with Lewy bodies, DLB. Their diagnosis, especially in ...

Cognitive deficits in progressive supranuclear palsy, Parkinson's disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction.

Groups of patients with idiopathic Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy or Steele-Richardson-Olszewski syndrome, matched for overall clinical disability, were compared using three computerised cognitive tests previously shown to be sensitive to frontal lobe dysfunction. On a test of planning based on the Tower of London task, all three groups were imp...